Detailed view for GL50803_92977

Basic information

TDR Targets ID: 812329
Giardia lamblia, Reverse transcriptase/endonuclease, putative
Source Database / ID:  GiardiaDB  

pI: 10.0249 | Length (AA): 144 | MW (Da): 16428 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00078   Reverse transcriptase (RNA-dependent DNA polymerase)

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 143 5hhj (A) 92 234 12.00 0.000000064 0.01 1.05166 0.5
24 78 2dgj (A) 143 196 31.00 0.51 0.01 0.604944 0.31

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126627)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG11231   CG11231 gene product from transcript CG11231-RA
Echinococcus granulosus EgrG_000774300   gastrula zinc finger protein xFG20 1
Giardia lamblia GL50803_92977   Reverse transcriptase/endonuclease, putative
Leishmania donovani LdBPK_201590.1   hypothetical protein, unknown function
Leishmania infantum LinJ.20.1590   hypothetical protein, unknown function
Leishmania major LmjF.20.1750   hypothetical protein
Leishmania major LmjF.20.1540   hypothetical protein, unknown function
Leishmania mexicana LmxM.20.1540   hypothetical protein, unknown function
Schistosoma japonicum Sjp_0316270   expressed protein
Schistosoma japonicum Sjp_0306130   IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing
Schistosoma mansoni Smp_186470   hypothetical protein
Schistosoma mansoni Smp_186490   hypothetical protein
Schmidtea mediterranea mk4.002710.04  
Trypanosoma brucei gambiense Tbg972.3.3580   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg972.5.3100   hypothetical protein, unlikely
Trypanosoma brucei gambiense Tbg972.10.20   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg972.8.8010  
Trypanosoma brucei gambiense Tbg972.5.3110   hypothetical protein, unlikely
Trypanosoma brucei gambiense Tbg972.11.4440  
Trypanosoma brucei gambiense Tbg972.8.6720  
Trypanosoma brucei gambiense Tbg972.11.18170   hypothetical protein, conserved
Trypanosoma brucei Tb11.v5.1020   retrotransposon hot spot (RHS) protein, putative
Trypanosoma brucei Tb927.10.16200   Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative
Trypanosoma congolense TcIL3000_0_24740   Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative
Trypanosoma congolense TcIL3000_0_05970   RNase H/C2H2 type zinc-finger (2 copies)/C2H2-type zinc finger containing protein, putative
Trypanosoma congolense TcIL3000_0_05880   reverse transcriptase (RNA-dependent DNA polymerase), putative
Trypanosoma congolense TcIL3000_0_38320   Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase)/RNase H, putative
Trypanosoma congolense TcIL3000_0_32200   Reverse transcriptase (RNA-dependent DNA polymerase)/RNase H, putative
Trypanosoma congolense TcIL3000_0_37120   Endonuclease-reverse transcriptase, putative
Trypanosoma congolense TcIL3000_0_28460   RNase H, putative
Trypanosoma congolense TcIL3000_0_39430   Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative
Trypanosoma congolense TcIL3000_0_49660   Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative
Trypanosoma congolense TcIL3000_0_14950   RNase H, putative
Trypanosoma congolense TcIL3000_0_43720   RNase H/Zinc finger, C2H2 type, putative
Trypanosoma congolense TcIL3000_0_17230   reverse transcriptase (RNA-dependent DNA polymerase), putative
Trypanosoma congolense TcIL3000_0_43730   Endonuclease-reverse transcriptase, putative
Trypanosoma congolense TcIL3000_0_58830   Endonuclease-reverse transcriptase, putative
Trypanosoma congolense TcIL3000_0_32280   Zinc finger, C2H2 type/C2H2-type zinc finger containing protein, putative
Trypanosoma congolense TcIL3000_0_22180   Endonuclease-reverse transcriptase, putative
Trypanosoma congolense TcIL3000_0_49570   Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative
Trypanosoma congolense TcIL3000_0_45590   Endonuclease-reverse transcriptase, putative
Trypanosoma congolense TcIL3000_0_28690   Endonuclease-reverse transcriptase, putative
Trypanosoma congolense TcIL3000_0_28760   Reverse transcriptase (RNA-dependent DNA polymerase)/RNase H/Zinc finger, C2H2 type, putative
Trypanosoma congolense TcIL3000_0_49560   Reverse transcriptase (RNA-dependent DNA polymerase)/RNase H/Zinc finger, C2H2 type/C2H2-type zinc finger containing protein, pu
Trypanosoma congolense TcIL3000_0_18610   Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase)/RNase H, putative
Trypanosoma congolense TcIL3000_0_49670   RNase H/Zinc finger, C2H2 type/C2H2-type zinc finger containing protein, putative
Trypanosoma congolense TcIL3000_0_03680   Reverse transcriptase (RNA-dependent DNA polymerase)/RNase H/Zinc finger, C2H2 type/C2H2-type zinc finger containing protein, pu
Trypanosoma cruzi TcCLB.508681.31   hypothetical protein
Trypanosoma cruzi TcCLB.510481.30   hypothetical protein, conserved

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier GL50803_92977 (Giardia lamblia), Reverse transcriptase/endonuclease, putative
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